| SHORT COMMUNICATION |
|
| Year : 2016 | Volume
: 5
| Issue : 1 | Page : 206 |
|
|
Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?
Fariba Iraji1, Nabet Tajmirriahi2, Iman Momeni1, Kioumars Jamshidi1, Fazlollah Hashemzehi1, Amir Hossein Siadat1, Alireza Asemi Esfahani1
1 Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Dermatology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Correspondence Address:
Dr. Nabet Tajmirriahi
Assisstant Professor of Dermatology, Department of Dermatology, School of Medicine, Ilam University of Medical Sciences, Ilam
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2277-9175.191002
|
|
|
Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.
Materials and Methods: Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.
Results: There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, P = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, P = 0.38).
Conclusion: This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
