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Year : 2021  |  Volume : 10  |  Issue : 1  |  Page : 26

Anaplastic large cell lymphoma, giant cell-rich, involving a nonimplant breast: A case report and review of the literature

Department of Laboratory and Blood Bank, Anatomic Pathology Section, King Faisal Hospital, Makkah, Kingdom of Saudi Arabia

Correspondence Address:
Dr. Rana Shaker Al-Zaidi
Department of Laboratory and Blood Bank, Anatomic Pathology Section, King Faisal Hospital, Makkah
Kingdom of Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/abr.abr_298_20

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Primary breast lymphomas are uncommon tumors and account for <1% of all malignant neoplasms of the breast. They are almost always of non-Hodgkin type, with B-cell lymphomas being the most common subtype. Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma that can involve the breast. Most of the articles in the literature describe ALCL in association with breast implants. We present a 48-year-old woman with a left breast enlargement and no history of an implant. Microscopic sections showed a high-grade CD30-positive lymphoid neoplasm with frequent giant cells, which turned out to be a primary ALCL of the breast, giant cell-rich pattern. To our knowledge, no cases of primary ALCL, giant cell-rich variant, have been reported in the breast in the absence of an implant making our case unique.

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