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Year : 2022  |  Volume : 11  |  Issue : 1  |  Page : 98

A review of studies on Candida species in Peninsular Malaysia

1 Faculty of Medicine, AIMST University, Malaysia
2 Faculty of Medicine, RCSI and UCD Malaysia Campus, Penang, Malaysia
3 Faculty of Medicine, Bioscience and Nursing MAHASA University, Selangor, Malaysia
4 Department of Pathology, Hospital Sultan Abdul Halim, Kedah, Malaysia
5 Faculty of Medicine, Manipal University College Malaysia, Melaka, Malaysia

Correspondence Address:
Miss. Humaira Farooq
AIMST University, Faculty of Medicine, Department of Medical Microbiology, Batu 3 1/2, Bukit Air Nasi, Jalan Bedong—Semeling, 08100 Bedong, Kedah
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/abr.abr_3_22

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Data on the epidemiology and the antifungal susceptibility of Candida species infections in Malaysia is still limited. The study aimed to review and compare studies reporting the prevalence of Candida species and antifungal susceptibility of Candida infections in Peninsular Malaysia. Data from 22 studies published between 2009 and 2018. Data was collected using National Center for Biotechnology Information and Google Scholar using the keywords “Candida and Malaysia.” Around 19 Candida species were identified in a total of 35,608 Candida isolates analyzed in these studies. In most studies examined, C. albicans (66.3%) was the predominant species, followed by C. glabrata (11.7%), C. parapsilosis (10.7%), C. tropicalis (9.5%), and C. krusei (1.19%). Vaginal swabs yielded the most isolates, followed by the respiratory system, urine, blood, oral, pus, and other locations. The demographic, racial, and gender data were recorded only in two studies. Totally, eight studies examined 396 isolates for antifungal susceptibility to common antifungal medications. The average antifungal susceptibility of isolates and efficacy of drugs in these studies ranged between 45 and 99% for most common antifungal drugs. Caspofungin had the highest susceptibility at 99%, whereas itraconazole had the lowest at only 45%. Overall, this review provided a comprehensive summary of all the current research on predominant Candida species in Peninsular Malaysia.

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