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Effects of teriparatide on clinical and radiologic long-term outcomes after fixation of pertrochanteric hip fractures
Mehdi Hosseini Khameneh1, Mona Gorji2, Meisam Jafari Kafi-Ababdi3, Farsad Biglari3, Morteza Gholipour4, Keivan Asadi5, Amir Sabbaghzadeh4
1 Clinical Research Development Unit of Akhtar Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Orthopedic Surgery, Shohada-E Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Clinical Research Development Unit of Akhtar Hospital, Shahid Beheshti University of Medical Sciences; Department of Orthopedic Surgery, Shohada-E Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Clinical Research Development Unit of Akhtar Hospital, Shahid Beheshti University of Medical Sciences; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Correspondence Address:
Dr. Amir Sabbaghzadeh
Department of Orthopedic Surgery, Shohada-E Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/abr.abr_127_22
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Background: Pertrochanteric hip fractures are common and among serious injuries of the old population with considerable mortality and morbidity. The aim of this study was to evaluate long-term effects of recombinant human parathyroid hormone on postoperative clinical and radiologic outcomes in elderly patients with pertrochanteric hip fractures.
Materials and Methods: Between 2016 and 2019, we prospectively assessed 80 patients with pertrochanteric hip fractures who underwent reduction and internal fixation with a dynamic hip screw. Patients were divided randomly into two groups. About 40 patients in the control group who received supplementary calcium (1000 mg/day) and vitamin D (800 UI/day), and 40 others who were treated additionally with 20–28 mg daily teriparatide for three months post-operatively. The functional and radiologic assessment was done using visual analog scale (VAS), Harris hip score (HSS), and standard radiographs of the hip.
Results: At the final follow-up, there was a significant difference between the two groups regarding average HSS (68.38 in the control group versus 74.12 in the treatment group, P-value <0.001). VAS score was also significantly lower in the treatment group (P-value <0.001). Regarding radiographic evidence of union, the results were not statistically different between the two groups.
Conclusions: The current study illustrated that short-term daily administration of teriparatide improves long-term functional outcome after pertrochanteric hip fracture fixation and can reduce the pain but does not affect union and callus formation.
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