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Year : 2023  |  Volume : 12  |  Issue : 1  |  Page : 159

Association of lymphovascular space invasion (LVSI) with histological tumor grade and myometrial invasion in endometrial carcinoma: A review study

1 Pathologist, Iranian Medical and Pathology Laboratory, Zahedan, Iran
2 Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Azita Rafiee
Pathologist, Iranian Medical and Pathology Laboratory, Zahedan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/abr.abr_52_23

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Endometrial carcinoma is one of the most frequent gynecological cancers in developed countries. Lymphovascular space invasion (LVSI), histological grade, and myometrial invasion (MMI) are important prognostic factors of endometrial carcinoma. LVSI is considered an independent poor prognostic factor in endometrial carcinoma. Based on the importance of LVSI, this study aimed to discuss the association of LVSI with tumor grade and MMI. A search of PubMed, EMBASE, Web of Science, Scopus, Google Scholar, and Cochrane Library was carried out to collect related studies. Consequently, most studies showed that LVSI is significantly associated with higher histologic grade and deep MMI.

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