Users Online: 3057
Home
About us
Editorial board
Search
Browse articles
Submit article
Ahead of Print
Instructions
Subscribe
Contacts
Login
» Articles published in the past year
To view other articles click corresponding year from the navigation links on the side bar.
All
|
Brief Communication
|
Brief Reports
|
Case Report and Literature Review
|
Case Reports
|
Editorial
|
Erratum
|
Letter to Editor
|
Letters to Editor
|
Notice of Retraction
|
Original Article
|
Original Articles
|
Research Articles
|
Review Articles
|
Review Report
|
Short Communications
|
Systematic Review
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Show all abstracts
Show selected abstracts
Export selected to
Add to my list
Original Article:
Value of D-dimer as a diagnostic marker of infection associated with orthopedic implants
Adel Ebrahimpour, Mohammad Ali Okhovatpour, Ali Tabrizi, Mahsa Bakhshmandi
Adv Biomed Res
2021, 10:28 (29 September 2021)
DOI
:10.4103/abr.abr_277_20
Background:
Recently, the D-dimer biomarker has gained the researchers' attention for predicting infections. We aimed to determine the relationship between this marker and other inflammatory markers involved in orthopedic implant-associated infections.
Materials and Methods:
In this study, all patients diagnosed with an orthopedic implant-associated infection were investigated in 3 years. The serum level of D-dimer, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) was measured. Infection was diagnosed based on the clinical and culture results of biopsy samples.
Results:
The cultured microorganisms, detected in 26 patients with infections, included
Staphylococcus aureus
(
n
= 13, 50%),
Staphylococcus epidermidis
(
n
= 2, 7.7%),
Klebsiella aerogenes
(
n
= 8, 30.8%), and
Pseudomonas aeruginosa
(
n
= 3, 11. 5%). Based on laboratory findings, there was a significant difference in the CRP level and ESR (
P
= 0.001). Although the level of D-dimer was higher in infected patients, compared to the controls (992.6 ± 667.2 vs. 690.1 ± 250.2 ng/mL), the difference was not statistically significant. There was no significant correlation between the elevated D-dimer level and CRP level, whereas ESR had a positive correlation with the elevated D-dimer level (
r
= 0.6,
P
= 0.03). The sensitivity, specificity, and positive predictive value (PPV) of D-dimer in the prediction of infection were 65%, 57%, and 45%, respectively. Furthermore, the sensitivity, specificity, and PPV of CRP were 100%, 92.3%, and 95%, respectively, whereas the corresponding values for ESR were 85%, 69.2%, and 62%, respectively.
Conclusion:
Measurement of the serum D-dimer level is not efficient for the diagnosis of orthopedic implant-associated infections due to its low predictive value. Furthermore, there was no significant correlation between the serum D-dimer level and CRP.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Original Article:
Determination of capsular serotypes, antibiotic susceptibility pattern, and molecular mechanism of erythromycin resistance among clinical isolates of Group B
Streptococcus
in Isfahan, Iran
Tahereh Motallebirad, Hossein Fazeli, Davood Azadi, Dariush Shokri, Sharareh Moghim, Bahram Nasr Esfahani
Adv Biomed Res
2021, 10:27 (29 September 2021)
DOI
:10.4103/abr.abr_269_20
Background:
Documented streptococcal resistance to erythromycin has recently been raised. The aim of this study is to identify the molecular mechanism of erythromycin resistance among group B
Streptococcus
(GBS) strains and to correlate with the clinical origin of strains.
Materials and Methods:
A total number of 134 colonizing (
n
= 36), invasive (
n
= 36), noninvasive (
n
= 46), and asymptomatic (
n
= 16) GBS isolates were characterized by the detection of
dltS
gene, capsular serotyping, antibiotic susceptibility profiles using disc diffusion method, and screening of the
ermB, ermTR
, and
mefA
resistance genes.
Results:
The distribution of capsular serotypes was as follow: serotype III (24.6%), Ia (21.6%), V (17.9%), Ib (14.9%), II (8.9%), IV (8.9%), VI (1.5%), and VII (1.5%). From 134 GBS isolates, 51 (38%) isolates were resistant to erythromycin. The constitutive macrolide lincosamide streptogrmin B (MLSB) was the most common resistance phenotype (62.7%), followed by inducible MLSB (27.4%) and M phenotype (9.8%). Erythromycin resistance rate was higher among asymptomatic GBS strains (13/16, 81.2%). Serotype III was the most prevalent type among resistant isolates (41.1%). The
ermB
gene highly distributed among resistant strains (64.7%), followed by
ermTR
(21.5%) and
mefA
(9.8%). The
ermB
gene was related to constitutive MLSB phenotype (84.3%,
P
< 0.05) and serotypes III (61.9%), Ib (87.5%), and V (83.3%). All M phenotype strains harbored
mefA
gene and were in association with serotype Ia (90%).
Conclusion:
The current study suggests that ribosomal modification with
erm
genes is the main mechanism of erythromycin resistance. Because of relatively high prevalence of erythromycin resistance, double disc test highly recommended for GBS disease treatment and intrapartum prophylaxis among penicillin intolerant patients in our region.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Case Report:
Anaplastic large cell lymphoma, giant cell-rich, involving a nonimplant breast: A case report and review of the literature
Rana Shaker Al-Zaidi, Nasir I Al-Noor
Adv Biomed Res
2021, 10:26 (29 September 2021)
DOI
:10.4103/abr.abr_298_20
Primary breast lymphomas are uncommon tumors and account for <1% of all malignant neoplasms of the breast. They are almost always of non-Hodgkin type, with B-cell lymphomas being the most common subtype. Anaplastic large cell lymphoma (ALCL) is a rare T-cell lymphoma that can involve the breast. Most of the articles in the literature describe ALCL in association with breast implants. We present a 48-year-old woman with a left breast enlargement and no history of an implant. Microscopic sections showed a high-grade CD30-positive lymphoid neoplasm with frequent giant cells, which turned out to be a primary ALCL of the breast, giant cell-rich pattern. To our knowledge, no cases of primary ALCL, giant cell-rich variant, have been reported in the breast in the absence of an implant making our case unique.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Case Report:
Unexpected positive effects of rituximab and corticosteroids on COVID-19 in a patient suffering from granulomatosis with polyangiitis
Mansour Salesi, Behrokh Shojaie, Zohre Naderi
Adv Biomed Res
2021, 10:25 (29 September 2021)
DOI
:10.4103/abr.abr_266_20
The COVID-19 pandemic has raised concerns among physicians and patients with autoimmune disorders about how this viral infection affects the patients receiving immunosuppressive drugs. There are speculations about a higher incidence and severity of COVID-19 in patients receiving a variety of immunosuppressant drugs. However, we reported the rapid recovery from COVID-19 in a 67-year-old male with granulomatosis with polyangiitis who did not experience severe symptoms of the COVID-19 as expected, despite having a history of serious lung involvement due to the autoimmune disease. He received conventional medications to treat COVID-19, though he had been receiving rituximab and corticosteroids before the onset of COVID-19 symptoms. Prevention of the cytokine storm caused by SARS-CoV-2 infection owing to taking the immunosuppressive drugs (rituximab and corticosteroids) could be a reason for these unexpected observations. Therefore, this case showed that taking immunosuppressive drugs is unlikely to be directly related to the increased severity of COVID-19.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Review Article:
Triage room principles and recommendations for 2019 novel coronavirus
Arvin Barzanji, Kamel Abdi, Mokhtar Yaghobi, Daem Roshani, Aram Karimian
Adv Biomed Res
2021, 10:24 (29 September 2021)
DOI
:10.4103/abr.abr_127_20
Triage becomes necessary when resources and time are not sufficient to provide the best possible services to all patients. This condition is more common in situations with a large number of casualties, like infectious epidemics. What is apparent is that, in the case of a widespread outbreak of infectious disease, hospitals are on the front lines of infected patient admission and treatment. Since the training of health-care workers is one of the most important pillars of preventive measures in controlling this pandemic, this study was conducted with the aim of expressing the principles of triage of infectious disease epidemic with a COVID-19 approach.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Sword Plugin for Repository]
Beta
Original Article:
Isolation and characterization of methylated flavones from
Artemisia kermanensis
Zeinab Yazdiniapour, Afsaneh Yegdaneh, Soudeh Akbari
Adv Biomed Res
2021, 10:23 (29 September 2021)
DOI
:10.4103/abr.abr_1_21
Background:
Artemisia kermanensis Podl
. is a green aromatic perennial shrub that belongs to the family
Asteraceae
and it grows widely in central deserts and south-eastern mountains of Iran such as Taftan Mountain in Sistan and Baluchestan Province.
Artemisia
species have been used traditionally as a remedy for various feverous diseases, including malaria, treatment of colds, infections, parasites, inflammations of the liver, as well as dyspepsia, diabetes, hypertension, and so many other conditions.
Materials and Methods:
Air-dried
A. kermanensis
extraction from all parts of the plant was done using different organic solvents. The methanolic extract was selected for isolation of flavonoids, using thin-layer chromatography. The chemical structures of the isolated compounds were determined based on analysis of mass and nuclear magnetic resonance spectra.
Results:
Two flavone aglycones were isolated and identified for the first time from this plant's methanolic extract, including 5,7-dihydroxy-3',4',6-trimethoxyflavone (eupatilin) and 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone.
Conclusions:
Eupatilin is known for its anticancer, antioxidant, and anti
-
inflammatory activities. In future researches on
A. kermanensis
, as a rich source of these flavone compounds, it is wise to investigate for the proven eupatilin's biological activities that have been mentioned.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (1) ]
[Sword Plugin for Repository]
Beta
Feedback
Subscribe
Advanced Search
Month wise articles
Figures next to the month indicate the number of articles in that month
2022
April
[
9
]
March
[
8
]
February
[
9
]
January
[
10
]
2021
December
[
10
]
November
[
11
]
October
[
5
]
September
[
6
]
August
[
2
]
July
[
4
]
June
[
3
]
May
[
1
]
March
[
2
]
February
[
4
]
January
[
6
]
2020
December
[
8
]
November
[
7
]
October
[
13
]
September
[
10
]
August
[
10
]
July
[
7
]
June
[
4
]
May
[
5
]
April
[
5
]
March
[
3
]
February
[
4
]
January
[
5
]
2019
December
[
2
]
November
[
5
]
October
[
5
]
September
[
7
]
August
[
6
]
July
[
3
]
June
[
7
]
May
[
5
]
April
[
8
]
March
[
6
]
February
[
8
]
January
[
10
]
2018
December
[
9
]
November
[
9
]
October
[
11
]
September
[
5
]
August
[
10
]
July
[
10
]
June
[
13
]
May
[
17
]
April
[
17
]
March
[
19
]
February
[
19
]
January
[
20
]
2017
December
[
13
]
November
[
21
]
October
[
12
]
September
[
9
]
August
[
15
]
July
[
22
]
June
[
11
]
May
[
14
]
April
[
14
]
March
[
21
]
February
[
8
]
January
[
8
]
2016
December
[
17
]
November
[
20
]
October
[
12
]
September
[
9
]
August
[
19
]
July
[
16
]
June
[
17
]
May
[
17
]
April
[
16
]
March
[
36
]
February
[
14
]
January
[
14
]
2015
December
[
2
]
November
[
15
]
October
[
25
]
September
[
29
]
August
[
29
]
July
[
31
]
June
[
11
]
May
[
39
]
March
[
15
]
February
[
29
]
January
[
34
]
2014
December
[
23
]
November
[
25
]
October
[
18
]
September
[
19
]
August
[
22
]
July
[
13
]
June
[
11
]
May
[
22
]
April
[
2
]
March
[
24
]
February
[
11
]
January
[
77
]
2013
November
[
10
]
October
[
5
]
August
[
1
]
July
[
23
]
June
[
11
]
March
[
42
]
2012
December
[
4
]
October
[
17
]
August
[
34
]
July
[
15
]
May
[
10
]
March
[
7
]
1900
January
[
1
]
Sitemap
|
What's New
Feedback
|
Copyright and Disclaimer
|
Privacy Notice
© Advanced Biomedical Research | Published by Wolters Kluwer -
Medknow
Online since 15 January, 2012