Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 11  |  Issue : 1  |  Page : 64-

Evaluation of diagnostic accuracy of alpha-fodrin antibody in Iranian patients with Sjogren's disease


Alireza Rostamian1, Azar Baradaran2, Peyman Mottaghi3, Mansour Salesi3, Mansour Karimifar3, Vahid Mansouri4 
1 Student Research Committee, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Dr. Azar Baradaran
Department of Pathology, Isfahan University of Medical Sciences, Isfahan
Iran

Background: Sjogren's syndrome, as a chronic autoimmune disease, involves in lymphocytic infiltration in the exocrine glands. As the result of exocrine glands disruption, the clinical hallmark of this disease including dryness of mouth and eyes along with fatigue and joint pain occur. However, heterogeneity of clinical presentations among newly diagnosed adult patients with Sjogren's syndrome leads to difficulty in its diagnosis. One of the diagnostic criteria for Sjogren's syndrome is the presence of autoantibodies in patient serum. One of the novel biomarkers suggested for diagnosis of Sjogren is alpha-fodrin antibody. In this study, we aimed to evaluate the diagnostic power of anti-α-fodrin antibody among the Iranian population for the first time. Materials and Methods: We recruited 82 individuals in this study. Alpha-fodrin were measured in case and control with Elisa kit as 16.71 (9.84) and 18.44 (11.54). Results: There was no any significant difference between two groups regarding alpha-fodrin level (P = 0.35). Then we applied the receiver operating characteristic (ROC) curve analysis to determine the predictive value of alpha-fodrin for diagnosing Sjogren's disease. The area under curve of the ROC curve was calculated as 0.5453. Also, there were significant association between age and alpha-fodrin antibody. Conclusions: Alpha-fodrin test did not have acceptable predictive power for predicting Sjogren's disease; however, it could be associated with disease progression.


How to cite this article:
Rostamian A, Baradaran A, Mottaghi P, Salesi M, Karimifar M, Mansouri V. Evaluation of diagnostic accuracy of alpha-fodrin antibody in Iranian patients with Sjogren's disease.Adv Biomed Res 2022;11:64-64


How to cite this URL:
Rostamian A, Baradaran A, Mottaghi P, Salesi M, Karimifar M, Mansouri V. Evaluation of diagnostic accuracy of alpha-fodrin antibody in Iranian patients with Sjogren's disease. Adv Biomed Res [serial online] 2022 [cited 2022 Aug 14 ];11:64-64
Available from: https://www.advbiores.net/article.asp?issn=2277-9175;year=2022;volume=11;issue=1;spage=64;epage=64;aulast=Rostamian;type=0