Advanced Biomedical Research

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 11  |  Issue : 1  |  Page : 71-

Comparison between the effects of acetaminophen, dexmedetomidine, and normal saline infusion on pain severity after cataract surgery


Dariush Moradi Farsani1, Seyed Ali-Akbar Mortazavi2, Sanaz Masjedi3, Sayed Morteza Heidari4, Behzad Nazemroaya1 
1 Department of Anesthesiology, Al-Zahra Medical Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Seyed Ali-Akbar Mortazavi
Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Background: Cataract surgery is one of the most common eye surgeries, which is currently performed under topical anesthesia using sedative medications. Dexmedetomidine and acetaminophen are good candidates for analgesia in other circumstances, however, this study aimed to evaluate the effect of dexmedetomidine or acetaminophen infusion and normal saline (NS) alone compared with the control group on the severity of pain in cataract surgery. Materials and Methods: In this parallel randomized controlled clinical trial, the effect of dexmedetomidine or acetaminophen infusion and NS on level of pain, vital signs, recovery status, and surgeon satisfaction during cataract surgery were assessed. One hundred and thirty-five patients between the age of 50–80 years undergoing cataract surgery were recruited on a consecutive basis and randomized into three groups receiving acetaminophen (15 mg/kg), dexmedetomidine (0.5 μgr/kg), and NS. Baseline vital signs, blood pressure, arterial oxygen saturation, respiratory and heart rate at certain time-points including the start of surgery, 5, 10, and 15 min after surgery, after arrival to the recovery room, 20, 40, 60 min after recovery were measured. Pain intensity and drugs side effects were also recorded after surgery. Results: Level of respiratory depression was higher in patients receiving dexmedetomidine. Heart rate and oxygen saturation percentage had no significant differences in the three groups as well as pain intensity. Conclusions: Acetaminophen was as effective as dexmedetomidine with lower side effects and higher surgeons' satisfaction, without any interference with cardiovascular and respiratory parameters. Acetaminophen infusion should be considered as an acceptable analgesic drug for cataract surgery.


How to cite this article:
Moradi Farsani D, Mortazavi SA, Masjedi S, Heidari SM, Nazemroaya B. Comparison between the effects of acetaminophen, dexmedetomidine, and normal saline infusion on pain severity after cataract surgery.Adv Biomed Res 2022;11:71-71


How to cite this URL:
Moradi Farsani D, Mortazavi SA, Masjedi S, Heidari SM, Nazemroaya B. Comparison between the effects of acetaminophen, dexmedetomidine, and normal saline infusion on pain severity after cataract surgery. Adv Biomed Res [serial online] 2022 [cited 2022 Sep 27 ];11:71-71
Available from: https://www.advbiores.net/article.asp?issn=2277-9175;year=2022;volume=11;issue=1;spage=71;epage=71;aulast=Moradi;type=0